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Impairment of passive avoidance retention in rats by 8-OH-DPAT and antagonism of the effect of 8-OH-DPAT by NAN-190 and WAY-100635. 8-OH-DPAT (0.1 mg kg−1 s.c.) given 30 min and NAN-190 (1 mg kg−1 i.p.) or WAY-100635 (0.5 mg kg−1 i.p.) 45 min before the acquisition session. Values are mean±s.e.mean of 10–30 animals. **P<0.01 vs control; ††P<0.01 vs 8-OH-DPAT (one-way ANOVA, F5,88=11.9, followed by Student-Newman-Keul's post hoc test).
