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The modulatory actions of 20 μM cOA develop with similar, slow, kinetics. (a) Peak GABA evoked current immediately prior to cOA exposure (E0) were measured at the indicated time points (Et) and approach an asymptote at 10–12 min. (b) The number of excitatory events per 120 s bin pretreatment (N0) was measured after exposure to cOA (Nt) and declined with a very similar timecourse. Points represent mean±s.e.mean (n=4), throughout.
