Figure 3.

Effect of α,β-meATP on ATP-evoked responses in HEK-293 cells expressing recombinant rat P2X₄ receptors. Whole cell currents were induced by 10 μM ATP, before and in the presence of serially increasing concentrations of α,β-meATP. The inter-application time was 5 min, α,β-meATP was included at the appropriate concentration in the superfusate and U-tube drug application system. Symbols are mean±s.e.mean (n=9). A representative trace of currents elicited by 10 μM ATP following preincubation of α,β-meATP is also shown (B).