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Mefloquine inhibits the L-type Ca current. The data show current records (top) and changes in [Ca2+]i (as monitored by Indo-1) in a single myocyte before and after perfusing with 10 μM mefloquine. The membrane potential was held at −40 mv and 100 ms duration depolarizing pulses applied to 0 mV at 0.33 Hz. Under these conditions superfusion of the cell with 0.1% propylene glycol did not produce any alterations in the L-type Ca2+ current (not shown).
