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Kinetics of tacrolimus metabolite formation in primary porcine hepatocytes exposed to 3, 7 μmol l−1 tacrolimus for 0, 1, 2, 4 or 24 h starting on day 3 in culture. Metabolites were analysed by LC/electrospray-MS. Data is shown as mean±s.d. of at least three dishes (2×106 cells). (a) demethyl-tacrolimus (M1); (b) bisdemethyl-tacrolimus (M2), demethyl-hydroxy-tacrolimus (M3) and hydroxy-tacrolimus (M4).
