Figure 4.

Spontaneous motility of the rat isolated colon: concentration- and time-dependencies of the actions of the non-prostanoids BMY 45778, BMY 42393 and ONO-1301 and their effects on inhibitory responses elicited by cicaprost, nicotine and isoprenaline. A vertical broken line indicates the start of continuous exposure to non-prostanoid (or vehicle). (f) shows that cicaprost can overcome the antagonistic action of BMY 45778 (1 μM, 70–80 min exposure). Vertical bars are s.e.means; n=4–8 for all experiments; statistical comparisons of motilities of vehicle and non-prostanoid treated preparations (upper asterisks) and of inhibitory agonist-induced responses of vehicle and non-prostanoid treated preparations (lower asterisks): ^*P<0.05, ^**P<0.01, ^***P<0.001.