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The effect of SR 59230A (10 nM–1 μM) on β-adrenoceptor agonist-induced relaxation in rat thoracic aorta. Results are expressed as percentage relaxation of tone induced by noradrenaline (1 μM). Values are mean±s.e.mean of n observations. (a) Effect of SR 59230A (10 nM–1 μM) on relaxation induced by isoprenaline (in the presence of 0.3 μM propranolol) (n=5–19). (b) Effect of SR 59230A (10 nM–1 μM) on relaxation induced by CGP 12177A (n=4–5).
