Figure 5.

Effect of suramin on transients induced by UTP and ATP. Transients evoked by 3 μM UTP in a single hepatocyte were unaffected by the application of 25 or 50 μM suramin, but were inhibited when the concentration was increased to 75 μM. In the same cell the transients induced by 3 μM ATP were similarly unaffected by 50 μM suramin, but were blocked by 75 μM suramin. Inhibition of transients induced by ATP and UTP by the same concentration of suramin was observed in three out of three cells. The break in the x-axis represents a period of 30 min during which the cell was superfused with WME alone.