Figure 1.
Effect of (a) the NO synthase inhibitor, L-NOARG (100 μM) and guanylate cyclase inhibitor, ODQ (10 μM), on endothelium-dependent relaxations to BK in rings of bovine coronary artery contracted with U46619. (b) Effect of ODQ (10 μM) on endothelium-independent relaxations to the NO-donor, SNAP in similarly contracted rings of bovine coronary artery. Values (mean±s.e.mean from n=6 experiments) are expressed as a percentage reversal of the initial U46619-induced contraction. (+) indicates that Rmax values for all treatments significantly different from those obtained in control tissues (P<0.05 for Tukey-Kramer's t-statistic after one way ANOVA).