Figure 2.

(a) Plasma ACE activity in anaesthetized dogs given intravenous infusion of vehicle (saline+NaOH 1N; n=6), Z13752A in doses of 0.3 μmol kg⁻¹ ml⁻¹ (128 μg kg⁻¹ ml⁻¹; n=6) and 1.0 μmol kg⁻¹ ml⁻¹ (426 μg kg⁻¹ ml⁻¹; n=6) and of captopril in a dose of 0.3 μmol kg⁻¹ ml⁻¹ (65 μg kg⁻¹ ml⁻¹; n=6) over a period of 3 h. Values are means±s.e.mean; ^*P<0.05 compared to the vehicle controls. (b) Ex vivo determination of tissue ACE and NEP activities, measured in the lung and in the kidney, respectively, following intravenous infusion of vehicle (saline+NaOH 1N; n=8), Z13752A in doses of 0.3 μmol kg⁻¹ ml⁻¹ (128 μg kg⁻¹ ml⁻¹; n=6) and 1.0 μmol kg⁻¹ ml⁻¹ (426 μg kg⁻¹ ml⁻¹; n=8) and of captopril in a dose of 0.3 μmol kg⁻¹ ml⁻¹ (65 μg kg⁻¹ ml⁻¹; n=6) over a period of 3 h. Values are means±s.e.mean; ^*P<0.05 compared to the vehicle controls.