Figure 6.

The distribution of ventricular arrhythmias in control dogs, and in dogs infused with Z13752A, with and without icatibant, during a 25 min coronary artery occlusion followed, at the end of this period, by reperfusion. The ACE/NEP inhibitor markedly reduced the severity of these arrhythmias and 6/9 dogs survived the combined ischaemia-reperfusion insult. This protective effect was reversed by icatibant suggesting a role, in the protection, for bradykinin.