Figure 8.

(a) Changes in epicardial ST segment during a 25 min occlusion of the left anterior descending coronary artery in anaesthetized dogs given saline, Z13752A, icatibant and Z13752A in the presence of icatibant. The administration of the ACE/NEP inhibitor leads to a reduction in the severity of the ischaemia, an effect reversed by icatibant. Values are means±s.e.mean; ^*P<0.05 c.p. control group. (b) Changes in the degree of inhomogeneity of electrical activation during a 25 min occlusion of the left anterior descending coronary artery in control dogs, in dogs given Z13752A, in dogs given icatibant and in dogs given Z13752A in the presence of icatibant. The reduction in this index of the severity of ischaemia is reduced by Z13752A and, again, this is reversed by icatibant. Values are means±s.e.mean; ^*P<0.05 c.p. control group.