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. 2000 Mar;129(5):1007–1013. doi: 10.1038/sj.bjp.0703126

Figure 1.

Figure 1

Inhibition of IKs and IKr by 293B in guinea-pig ventricular cells. (A) An envelope test of tail currents. Superimposed current traces were obtained when the membrane was depolarized from −40 mV to +60 mV for various duration in the absence (a) and presence (b) of 5 μM E4031. The dotted lines indicate zero current level. (c), The ratio of tail current to time-dependent current. The data are average of six experiments and bars indicate s.e.mean. No bars are shown when the s.e.mean is smaller than the symbol size. (B) An envelope test of tail currents in the absence (a) and presence (b) of 100 μM 293B. The dotted lines indicate zero current level. (c), the 293B-sensitive current was measured by subtracting the current in the presence of 293B (b) from the control (a). (d), The ratio of tail current to time-dependent current. The data are average of three experiments.