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. 2000 Mar;129(5):943–952. doi: 10.1038/sj.bjp.0703141

Figure 1.

Figure 1

Bradykinin (BK)-induced endothelium-dependent triphasic changes in [Ca2+]i and force during phenylephrine (Phe)-induced sustained contraction in porcine renal artery. (a–c) The representative recordings of changes in [Ca2+]i (ratio) and force induced by 10−8 M (a) and 10−9 M (b) BK in the strips with endothelium, and by 10−8 M BK in the strips without endothelium (c). (d) 10−7 M Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8] bradykinin), a specific bradykinin B2 receptor antagonist completely abolished the 10−8 M BK-induced triphasic responses. Hoe 140 (10−7 M) were applied just prior to the initiation of contraction by Phe. BK was applied 15 min after the initiation of the precontraction by 10−6 M Phe. The levels of [Ca2+]i and force at rest and during the first Phe-induced sustained contraction were designated to be 0 and 100%, respectively.