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Percentage changes in rabbit femoral artery pressure (mean±s.e.mean) from baseline, in response to increasing doses of injected (a) isoprenaline, (b) forskolin or (c) dibutyryl cyclic AMP. In each case, dose-response curves are displayed before and after treatment with 1 μmol kg−1 L-NAME (n=6 for each). Treatment with L-NAME significantly blunted the reduction in measured intra-arterial pressure in response to each drug (P<0.0001 in each case).
