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. 2000 Mar;129(6):1251–1259. doi: 10.1038/sj.bjp.0703160

Figure 2.

Figure 2

Effect of in vivo CL316243 (4 h) treatment (1 mg kg−1) on β3a-AR and β3b-AR mRNA levels in WAT, BAT and ileum and on responses to CL316243 in ileum. (a,b) β3a-AR mRNA levels were significantly reduced in WAT (***P<0.001) and BAT (***P<0.001) but not ileum following treatment. β3b-AR mRNA levels were significantly reduced in WAT (***P<0.001) following treatment. Bars show mean±s.e.mean (n=5–6). (c) 4 h CL316243 treatment desensitized β3-AR mediated responses in mouse ileum with a significant reduction in the Rmax response of the tissue with no change in pEC50 (2-way ANOVA ***P<0.0001). Points show mean and vertical lines indicate s.e.mean (n=12–13).