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. 2000 Mar;129(6):1251–1259. doi: 10.1038/sj.bjp.0703160

Figure 3.

Figure 3

Effect of in vivo CL316243 (24 h) treatment (1 mg kg−1) on β3a-AR and β3b-AR mRNA levels in WAT, BAT and ileum and on responses to CL316243 in ileum. (a,b) β3a-AR and β3b-AR mRNA levels in WAT were significantly reduced (*P<0.05) following 24 h CL316243 treatment but levels were unaffected in BAT or ileum. Bars show mean±s.e.mean (n=5–6). (c) β3-AR mediated responses in ileum were desensitized following treatment, with the Rmax responses to CL316243 significantly reduced with no change in pEC50 values (2-way ANOVA ***P<0.0001). Points show mean and vertical lines indicate s.e.mean (n=6).