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Dose-related reactivation of CIA by LPS. Mice were immunized with CII on day 0 followed by a booster injection on day 21 as described in Methods. On day 50, saline and the indicated doses of LPS were i.p. injected. The severity of arthritis was determined on day 50, i.e. immediately before administration of LPS and on day 55. Bars show the mean±s.e.mean of ten mice. *P<0.05 versus saline, Mann-Whitney U-test. Data are representative of three experiments.
