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Histologic changes in tarsal joints of mice with CIA following administration of LPS. Mice were immunized with CII on day 0 followed by a booster injection on day 21 as described in Methods. Saline or 5 μg of LPS was i.p. injected on day 50. Tarsal joints were histologically examined on day 50, i.e. immediately before injection of LPS (A) and on day 55 after injection of LPS (B). Haematoxylin and eosin stained, ×200 (original magnification).
