Figure 5.

Inhibition of SUR1-Kir6.2 channels in transfected cells by glyburide. (A) The reduction in amplitude of whole cell currents with increasing concentrations of glyburide at each test potential. (B) Concentration-response curve for the inhibition of current amplitude by glyburide (at −100 mV). The fraction of current remaining (I) was plotted as a fraction of the control current (Io) that was obtained in the absence of glyburide. The IC₅₀ value of glyburide is 0.92±0.01 nM (Hill coefficient=1.0±0.2; n=6).