Figure 5.

(A) The effects of NSD-1015 (25 mg kg⁻¹ i.p.) or saline pretreatment on locomotor activity and disability scores induced by A-86929 (0.04–0.08 mg kg⁻¹ s.c.) co-administered with quinpirole (0.05–0.1 mg kg⁻¹ i.p.) accumulated over 2 h (n=4) in MPTP-lesioned marmosets. (B) The effects of a subthreshold dose of L-DOPA (5 mg kg⁻¹ s.c.) on locomotor activity and disability scores induced by A-86929 (0.04 mg kg⁻¹ s.c.) and quinpirole (0.1 mg kg⁻¹ i.p.) following inhibition of AADC with NSD-1015 (25 mg kg⁻¹ i.p.) MPTP-lesioned marmosets. NSD-1015 was administered 60 min prior to L-DOPA, and 30 min later A86929 and quinpirole were administered combination. Results are accumulated over 2 h (n=4). The data are expressed as mean±s.e.mean ^*P<0.05 vs saline pretreatment group.