Figure 5.

Effect of in vivo administration of dexamethasone on GM-CSF-induced colony formation. The data are mean±s.e.mean of the number of myeloid colonies formed after 7 days by cultured bone-marrow from BALB/c mice that had been injected with saline (closed bars), or dexamethasone, 5 mg kg⁻¹ (open bars) or 1 mg kg⁻¹ (cross-hatched bars), 24 h before bone-marrow harvest. −, cultures with GM-CSF (2 ng ml⁻¹) alone; +, cultures with GM-CSF plus dexamethasone, 10⁻⁷ M. Data are derived from seven experiments. Asterisks indicate significant difference relative to the GM-CSF cultures from saline-injected mice (P<0.001 in all cases).