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Metabolism of 14C-cisapride by human liver microsomes. (A) illustrates the HPLC separation profile of the cisapride reference compounds. (B) is representative of a typical HPLC metabolic profile for 14C-cisapride in the presence of human liver microsomes (n=4). The metabolites, M1, M2, M5, M6 and M7, were identified by co-chromatography and mass spectrometry. M4 was identified by mass spectrometry. P=parent compound.
