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Cumulative concentration-effect curves described in terms (a,c) increase in airway resistance (%RL) and (b,d) decrease in dynamic compliance (%Cdyn) from basal levels in response to aerosolized histamine prior to antigen challenge and following antigen challenge in animals treated with either heparin (1000 U.ml−1) or heparin vehicle (chlorocresol, 0.03%), prior to (a,b) and following (c,d) antigen challenge. Data presented as the mean±standard error of the mean from 9–14 animals.
