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Effects of 20 min exposure to vehicle, 17β-estradiol, 8-Bromo-cyclic AMP, Sp-cyclic AMPS and 8-Bromo-cyclic GMP on relaxation responses to (a) levcromakalim and (b) SNP. Data are means±s.e.mean with n=6–8 in each case. Concentration-response curves obtained in the presence of 17β-estradiol, 8-Bromo-cyclic AMP and Sp-cyclic AMPS were significantly different to the vehicle-control curve (*P<0.05).
