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. 2000 May;130(1):146–152. doi: 10.1038/sj.bjp.0703294

Figure 2.

Figure 2

Effect of 2-BFI and LSL61122 on morphine antinociception (A) the effect of increased doses of 2-BFI and LSL61122 were tested upon the antinociceptive response to a fixed dose of morphine (1 μg per mouse, i.c.v.). Imidazoline compounds were given 30 min before morphine administration. The data indicate the percentage of increase respect to the antinociceptive effect induced by morphine alone (35.6±2.8% MPE). (B) Dose-response curves for morphine antinociception in mice were constructed in the absence and presence of 2-BFI (10 μg per mouse). Antinociception was evaluated in the 52°C hot-water tail-flick test and is expressed as a percentage of the maximum possible effect (MPE). All values are means±s.e.mean from groups of 10–15 mice. *Significantly different from the control group receiving saline instead of imidazoline. Analysis of variance, Student-Newman-Keuls test, P<0.05.