Figure 5.

Isolated rat livers perfused with human serum. Individual effects of endothelin antagonists (five experiments in each group). The administration of 10⁻⁶ M BQ 123 and 10 min before the serum perfusion, partially reversed the effects of xenogeneic human serum, whereas that of 10⁻⁶ M BQ 788 had only marginal effect. ^*:P<0.01 vs controls; †:P<0.05 vs livers perfused with fresh human serum alone.