Figure 1.

Contractile response to cumulative doses of phenylephrine (PE) in endothelium denuded aortic rings from sham-operated rats and rats subjected to splanchnic ischaemia-reperfusion injury (SAO) treated with vehicle (1 ml kg⁻¹ i.v, 5 min after the onset of reperfusion), Cyclosporin A (CsA 0.25, 0.50 and 1 mg kg⁻¹ i.v. 5 min following the onset of reperfusion), L-NAME (5 mg kg⁻¹, 5 min following the onset of reperfusion) and 1400 W (20 mg kg⁻¹, 5 min following the onset of reperfusion). Aortae were removed 70 min following the onset of reperfusion. The occlusion period lasted 45 min. Each point represents the mean±s.e.mean of seven experiments. ^*P<0.05 vs SAO+vehicle. #P<0.01 vs SAO+vehicle.