Figure 1.
Effect of HX (3×10−4 M)/XO (64 mu ml−1) on the relaxant responses to 2 NO-boli (10−5 M) consecutively given with an interval of 8 min. On the left, the control situation is depicted where the strips receive the solvent of either HX or XO. In the presence of HX/XO (on the right), the relaxant response to NO became biphasic. Both phases are shown (1 and 2). The relaxations are expressed as a percentage of the response to the same stimulus before addition of interfering drugs. ***P<0.001: significantly different from the response before (paired t-test). HX=hypoxanthine; XO=xanthine oxidase.