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Effects of JTT-501 and troglitazone on blood biochemical parameters in ZDF rats. Blood samples were taken from tail vein weekly. Serum insulin (A), serum glucose (B), blood HbA1c (C), serum triglyceride (D), and serum cholesterol (E) were measured as described in Methods. Each point represents the mean±s.e.mean (n=8). ¶P<0.05, ¶¶P<0.01 vs lean (Student's t-test). *P<0.05, **P<0.01 vs ZDF control (ANOVA followed by Dunnett's test). †P<0.05, ††P<0.01 vs ZDF control (Student's t-test).
