Figure 6.

Graph showing how the increase in tone resulting from addition of L-NAME (100 μM) to endothelium-containing rings of porcine cerebral artery was affected following a 30 min pre-treatment with the mixed ET_A/ET_B endothelin receptor blocker SB209670 (1 μM), the cyclo-oxygenase inhibitor flurbiprofen (10 μM), the neurotoxin tetrodotoxin (1 μM), or the lipoxygenase inhibitors curcumin (30 μM), MK-886 (30 μM) and NDGA (30 μM). Each value is the mean±s.e.mean. 7–10 observations. ^***P<0.001 indicates a significant reduction.