Figure 3.

(A) Effect of betaxolol on the association rate of [³H]-BTX-B to rat cortical membranes. Membranes were incubated with 10 nM [³H]-BTX-B in the presence or absence of 100 μM betaxolol as described in Methods. (B) Effect of betaxolol on the dissociation rate of [³H]-BTX-B to rat cortical membranes. Membranes were incubated with 10 nM [³H]-BTX-B plus 300 μM veratridine in the absence or presence of 10 or 100 μM betaxolol as described in Methods. In (A) and (B) the results shown represent the mean of 3–4 independent experiments performed in duplicate. Error bars have been removed for the sake of clarity.