Figure 6.
Effects of taurine on a single KATP channel after rundown. Downward deflections in the current record indicate inward current. (A) Continuous recording of channel activity was performed after 8 min from excision, at −60 mV (Vm), with 150 mM KCl on both sides of the membrane in the absence (control) and in the presence of 30 mM concentration of taurine. The sulphonic aminoacid decreased the burst duration and prolonged the close time intervals within the bursts. (B) Kinetic analysis of the channel traces in A, performed within the bursts of openings. As shown, the open and close time distributions were fitted by two exponential functions not modified by taurine.