Figure 2.

Properties of zinc inhibition of GABA-induced currents in Purkinje cells. (A) The inhibitory effect of Zn²⁺ does not depend on GABA concentration. Responses to application of different concentrations of GABA and GABA+100 μM Zn²⁺ obtained from a single cell. (B) Rapid reversal of Zn²⁺ inhibition. Responses to 50 μM GABA in control, after preapplication of 100 μM Zn²⁺ and superposition of two traces. Interval between GABA applications was 90 s, duration of GABA exposure 1 s, zinc application was for 10 s (arrow) terminating at the beginning of trace 2. Recovery from the zinc effect occurs within less than 1 s.