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Relationship between agonist: antagonist binding affinity difference and functional intrinsic activity (I.A.), in HEK293 cells expressing human 5-HT1A receptors. Functional efficacy was determined by [35S]-GTPγS binding assays. (a) Shows the relationship between [3H]-8-OH-DPAT : [3H]-MPPF pKi difference and I.A. The correlation between [3H]-8-OH-DPAT : [3H]-spiperone pKi difference and I.A. is shown in (b).
