Figure 4.

Inhibition of YD-3 on the formation of inositol monophosphate caused by thrombin in washed rabbit platelets. [³H]-Myoinositol-labelled platelets were incubated with DMSO (0.5%, control) or YD-3 (5–100 μM) at 37°C for 3 min, thrombin (0.1 u ml⁻¹) was then added for another 6 min. All the experiments were carried out in the presence of LiCl (5 mM) and indomethacin (10 μM). Folds of the increase of IP are presented as mean±s.e.mean. ^*P<0.05, ^**P<0.01 and ^***P<0.01 as compared with the control (n=3).