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Effect of D600 on microcystin-LR-induced insulin secretion by RINm5F cells. After preincubation of 10 min with microcystin-LR (0.1–2 μM) the cells were incubated for 30 min with microcystin-LR both in the presence or absence of D600 (50 μM), as indicated in the figure. IRI (ordinate axis): immunoreactive insulin. Mean±s.e.mean, n=3–4. ANOVA, Newman-Keuls-test. Values marked with different symbols (#,$,&;@) are significantly different (P<0.05).
