Figure 3.

Effects of Hoe-140 (H, 300 μg kg⁻¹, i.v.), MGTA (M, 10 mg kg⁻¹, i.v.+20 mg kg⁻¹ 20 min⁻¹ infusion), Hoe-140+MGTA (H+M) and L-NAME (LN, 10 mg kg⁻¹, i.v.) on changes in (a) mean arterial pressure, (b) femoral blood flow and (c) femoral vascular conductance evoked by successive administration of captopril (CAP, 2 mg kg⁻¹, i.v.+1 mg kg⁻¹ 30 min⁻¹ infusion) and retrothiorphan (RT, 25 mg kg⁻¹, i.v.+12.5 mg kg⁻¹ 30 min⁻¹ infusion) in diabetic Sprague-Dawley rats (STZ-SDs). For each rat, values measured at 20, 25 and 30 min after the start of each infusion are averaged. Each column represents the mean value of n rats and the vertical T bar the s.e.mean. ^*P<0.05 and ^**P<0.01 vs CAP without pre-treatment or vs CAP+RT without pre-treatment (ANOVA followed by Dunnett's t-test).