Figure 4.

Effects of captopril (CAP, 2 mg kg⁻¹, i.v.+1 mg kg⁻¹ 30 min⁻¹ infusion), alone and in combination with retrothiorphan (RT, 25 mg kg⁻¹, i.v.+12.5 mg kg⁻¹ 30 min⁻¹ infusion), on (a) mean arterial pressure, (b) femoral blood flow and (c) femoral vascular conductance in control (C-BN, n=7) and diabetic (STZ-BN, n=4) Brown-Norway kininogen-deficient rats. For each rat, values measured at 20, 25 and 30 min after the start of each infusion are averaged. Each column represents the mean value and the T bar the s.e.mean. ^*P<0.05, ^**P<0.01 and ^***P<0.001 vs baseline; †††P<0.001 vs CAP alone (ANOVA for repeated measures followed by Newman-Keuls test).