Figure 4.

The effect of antidepressant drugs and cocaine on the CAT gene transcription induced by corticosterone (1 μM, 2 h) in LMCAT cells. IMI-imipramine; AMI-amitriptyline; DMI-desipramine; FLU- fluoxetine, and COCA-cocaine were used at a concentration of a 10 μM for 1, 3 or 5 days. Corticosterone (1 μM) was added 2 h before harvesting the cells for an assay of CAT enzyme activity (presented as fold induction in CAT activity). The data are presented as mean±s.e.mean, and the significance of differences between the means was evaluated by the Dunnett's test following a one-way analysis of variance (^**P<0.001 vs control group).