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(a) Effect of naproxen (10 mg kg−1) and NO-naproxen (16 mg kg−1) following oral treatment either from day 1–21 or from day 7–21 on IL-1β plasma levels. (b) Effect of naproxen (10 mg kg−1) and NO-naproxen (16 mg kg−1) following oral treatment either from day 1–21 or from day 7–21 on TNFα plasma levels. *P<0.05; **P<0.01 significantly different versus FA rats. #P<0.001 significantly different versus naïve animals.
