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Effect of S17092-1 on the recovery of Aβ40/42 produced by wild-type and Swedish mutated-βAPP-expressing cells. HEK293 cells expressing wild-type (a) or Swedish mutated (b) βAPP were treated for 7 h without (Ct) or with the indicated concentrations of S17092-1. Secretion media were then analysed for their Aβ40 or Aβ42 contents by sequential immunoprecipitation with FCA3542 and FCA3340, respectively, then immunological complexes were revealed as detailed in the Methods.
