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Effects of calmodulin inhibitors (W-7 and calmidazolium), EGTA and Ni2+ on bile acid-induced [NO2−] production in human endothelial cells. [NO2−] production was measured in control, in the presence of chenodeoxycholic acid (CDC, 300 μM), CDC (300 μM) plus calmodulin inhibitors (W-7 and calmidazolium (calmida)), EGTA (10 mM) or Ni2+ (1 mM) for 24 h. Each column represents the mean±s.d. value of six different preparations.
