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Concentration-response curves for acetylcholine in the guinea-pig mesenteric artery (MA) and middle cerebral artery (CA) in the absence and the presence of a combination of indomethacin (10 μM) and L-NNA (100 μM) or indomethacin and L-NNA plus ODQ (10 μM) or high K+ PPS (40 mM). Data are shown as the mean±s.e.mean from 5–7 separate experiments.
