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Concentration-response curves for acetylcholine in the guinea-pig mesenteric artery (MA) and middle cerebral artery (CA) in the presence of a combination of L-NNA (100 μM) plus indomethacin (10 μM) as the control and vessels pretreated with: clotrimazole (1 μM), AM404 (30 μM) or combination of AM404, apamin (3 μM) and iberiotoxin (0.1 μM). Data shown as the mean±s.e.mean from 5–6 separate experiments.
