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Concentration-response curves for acetylcholine in the guinea-pig mesenteric artery (MA) and middle cerebral artery (CA) in the presence of a combination of L-NNA (100 μM) plus indomethacin (10 μM) as the control and vessels pretreated with U73122 (1 μM) or AACOCF3 (1 μM). Data are shown as the mean±s.e.mean from six separate experiments.
