Figure 1.

Response-size (displayed as the area under the curve; AUC) of acetylcholine (ACh)-induced dilatation in isolated aortic rings from treated (zofenopril, ZOF, n=10; lisinopril, LIS, n=8; N-acetylcysteine, NAC, n=8) and untreated rats with chronic myocardial infarction (MI, n=11) or no-MI (n=8). Dilatations were studied in presence of 10 μmol l⁻¹ indomethacin, either with or without 100 μmol l⁻¹ N^G-mono-methy-L-arginine (L-NMMA) as indicated. The response-difference between both conditions representing the L-NMMA-sensitive part of the dilatation is shown in the small graph on the right-side top; identification of the bars from left to right is in the same order as below. Data are mean±s.e.mean; ^* indicates P<0.05 versus no-MI and # indicates P<0.05 versus MI.