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Application of gabapentin depresses the EPSC recorded from hyperalgesic animals. EPSCs were evoked every 30 s. Bath application of gabapentin (100 μM; 20 min) caused a reversible depression of the EPSC (A). In panel (B) traces representing (a) control, (b) and (c) after 10 and 13 min gabapentin perfusion respectively and (d) after 7 min washout are shown. (C) Histogram representing the mean inhibition of the EPSC in 15 out of 20 cells recorded.
