Figure 3.

The effect of PLA₂ inhibitors, MEK and MAPK inhibitors on EGF stimulated PGE₂ release from A549 cells. Cells were treated with EGF (E, 10 nM) plus either with sPLA₂ inhibitor ONO-RS-82, iPLA₂ inhibitor HELSS, cPLA₂ inhibitor AACOCF₃, p38 MAPK inhibitor SB 203580, MEK inhibitor PD 98059, ERK inhibitor apigenin or untreated as control (C) for 72 h. The data are presented as mean±s.e.mean, the concentrations of PGE₂ released in the media in pg ml⁻¹.