Skip to main content
. 2000 Oct;131(3):546–552. doi: 10.1038/sj.bjp.0703584

Figure 4.

Figure 4

Antagonism of prazosin-induced decrease of [35S]-GTPγS binding activity by KMD-3213 in the mutant alpha-1a AR. Specific binding of [35S]-GTPγS to the membrane from the CHO cells expressing the mutant alpha-1a AR was measured and various concentrations of KMD-3213 or prazosin with or without 10 nM KMD-3213 was added in the reaction mixture as described under Methods. Values were expressed as per cent of the binding obtained in the absence of the drug and are represented mean±s.e.mean from six experiments.